Sp1 binding activity increases in activated Ito cells. Gastroenterology. Cox AD, Garcia AM, Westwick JK, Kowalczyk JJ, Lewis MD. The role of Smad3 in mediating mouse hepatic stellate cell activation. Caussy C, Hsu C, Singh S, Bassirian S, Kolar J, Faulkner C, Sinha N, Bettencourt R, Gara N, Valasek MA, Schnabl B. Hellerbrand C, Jobin C, Iimuro Y, Licato L, Sartor RB. Circ Res. Liver Int. Age (Dordr). Autocrine expression of activated transforming growth factor-beta(1) induces apoptosis in normal rat liver. 2023 Jan 17; 1-6. A single promoter directs both housekeeping and erythroid preferential expression of the human ferrochelatase gene. Karthikeyan S, Levy JI, De Hoff P, Humphrey G, Birmingham A, Jepsen K. MiR-690 treatment causes decreased fibrosis and steatosis and restores specific Kupffer cell functions in NASH. Idh1 protects murine hepatocytes from endotoxin-induced oxidative stress by regulating the intracellular NADP(+)/NADPH ratio. Reversibility of Liver Fibrosis and Inactivation of Fibrogenic Myofibroblasts. JCI Insight. Activation of activating protein 1 during hepatic acute phase response. Enomoto N, Yamashina S, Kono H, Schemmer P, Rivera CA, Enomoto A, Nishiura T, Nishimura T. TNF receptor-associated factor-2 is involved in both IL-1 beta and TNF-alpha signaling cascades leading to NF-kappa B activation and IL-8 expression in human intestinal epithelial cells. 2018 12; 68(6):2059-2061. Arch Clin Biomed Res. Gastroenterology. Awareness, treatment, and control of vascular risk factors among stroke survivors. Transplantation. Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice. J Biol Chem. 2007 Aug; 47(2):307-9. Cancer Res. Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver. The focal adhesion kinase suppresses transformation-associated, anchorage-independent apoptosis in human breast cancer cells. 2019 07 23; 116(30):15184-15193. Mechanisms of liver fibrosis and its role in liver cancer. J Clin Invest. Moore-Morris T, Guimar?es-Camboa N, Banerjee I, Zambon AC. Clin Gastroenterol Hepatol. Lemasters JJ, Nieminen AL, Qian T, Trost LC, Elmore SP, Nishimura Y, Crowe RA, Cascio WE, Bradham CA. Investigating the role of the extracellular environment in modulating hepatic stellate cell biology with arrayed combinatorial microenvironments. Akt activation protects rat liver from ischemia/reperfusion injury. Caussy C, Hsu C, Lo MT, Liu A, Bettencourt R. Sphingosine kinase 1 promotes liver fibrosis by preventing miR-19b-3p-mediated inhibition of CCR2. Non-alcoholic steatohepatitis-induced fibrosis: Toll-like receptors, reactive oxygen species and Jun N-terminal kinase. # # # Media Contact: Alma Fisher, 619-543-6163, alfisher@ucsd.edu Differential expression of human lysyl hydroxylase genes, lysine hydroxylation, and cross-linking of type I collagen during osteoblastic differentiation in vitro. 2009 Sep; 1(8-9):513-24. DNA methylation represses the murine alpha 1(I) collagen promoter by an indirect mechanism. Neurology. 2001 Nov; 34(5):953-63. Kodama Y, Taura K, Miura K, Schnabl B, Osawa Y. Molecular pathogenesis of liver fibrosis. Arch Biochem Biophys. Mallat A, Praux AM, Serradeil-Le Gal C, Raufaste D, Gallois C. Differential regulation of hepatocyte DNA synthesis by cAMP in vitro in vivo. 2015 Apr; 61(4):1239-50. 1995 Sep; 9(9):1157-65. Bradham CA, Schemmer P, Stachlewitz RF, Thurman RG. 2009 Jan; 49(1):6-8. Hepatology. Dominant-negative TAK1 induces c-Myc and G(0) exit in liver. Hepatology. Gastroenterology. Gastroenterology. 2000 Mar; 15 Suppl:D20-5. 2017 02; 152(3):598-607.e2. Inhibition of both extracellular signal-regulated kinase and c-Jun kinase and upregulation of endothelin B receptors. 2012 Jun 12; 109(24):9448-53. A logical approach to the patient with jaundice. Estriol sensitizes rat Kupffer cells via gut-derived endotoxin. 2007 May; 132(6):2272-5. 2017 01; 65(1):78-88. Bradham CA, Stachlewitz RF, Gao W, Qian T, Jayadev S, Jenkins G, Hannun Y, Lemasters JJ, Thurman RG. J Immunol. Gut. 2020 Nov 03; 32(5):901. Gastroenterology. 2021; 8:790032. Origin of myofibroblasts in the fibrotic liver in mice. Campos Alberto E, Maclean E, Davidson C, Palikhe NS, Storie J, Tse C. Toll-like receptor 2-mediated intestinal injury and enteric tumor necrosis factor receptor I contribute to liver fibrosis in mice. 2021; 12(1):293-320. 1998 Jul 01; 102(1):107-14. 2008 Dec; 173(6):1617-27. Gene expression and cytokine and enzyme activation in the liver after a burn injury. Mitochondrial dysfunction in the pathogenesis of necrotic and apoptotic cell death. 2016 Mar; 13(3):126-8. Blockade of IL-17 signaling reverses alcohol-induced liver injury and excessive alcohol drinking in mice. Concanavalin A-induced liver cell damage: activation of intracellular pathways triggered by tumor necrosis factor in mice. Am J Physiol Gastrointest Liver Physiol. Weight Loss Decreases Magnetic Resonance Elastography Estimated Liver Stiffness in Nonalcoholic Fatty Liver Disease. 2013 Apr; 144(4):661-3. 1990 Jun; 11(6):909-15. Effects of three superoxide dismutase genes delivered with an adenovirus on graft function after transplantation of fatty livers in the rat. Liver Transpl. 1999; 8(3):151-63. Cell Metab. 2015 Sep; 42(5):582-90. 2004 Apr; 18(6):720-2. Meng F, Wang K, Aoyama T, Grivennikov SI, Paik Y, Scholten D, Cong M, Iwaisako K, Liu X, Zhang M, ?sterreicher CH, Stickel F, Ley K. Origin of myofibroblasts in liver fibrosis. Gastroenterology. Hepatology. Serum levels of alanine aminotransferase decrease with age in longitudinal analysis. Zinc finger protein 267 is up-regulated during the activation process of human hepatic stellate cells and functions as a negative transcriptional regulator of MMP-10. Gastroenterology. J Biol Chem. 1999 Jan 06; 1453(1):161-74. Recent advances in liver stem cell therapy. Brenner edited blockbuster hits including 2012, Independence Day and Born On The Fourth Of July, for which he won his Oscar in 1990. 1995 Jul; 22(1):241-51. Multiplex short tandem repeat profiling of immortalized hepatic stellate cell line Col-GFP HSC. 2008 Mar; 23 Suppl 1:S98-103. 1998 Oct; 27(3):192-8. 1990 Feb; 10(1):75-83. Am J Physiol. 2014 Apr 29; 63(16):1626-33. TNF alpha-induced hepatocyte apoptosis is associated with alterations of the cell cycle and decreased stem loop binding protein. Biology (Basel). Association between novel MRI-estimated pancreatic fat and liver histology-determined steatosis and fibrosis in non-alcoholic fatty liver disease. Dr. Brenner is Vice Chancellor for Health Sciences and Dean of the School of Medicine at the University of California, San Diego. J Biol Chem. J Hepatol. Kim RG, Nguyen P, Bettencourt R, Dulai PS, Haufe W, Hooker J. Sitagliptin vs. placebo for non-alcoholic fatty liver disease: A randomized controlled trial. DNase I-hypersensitive sites enhance alpha1(I) collagen gene expression in hepatic stellate cells. Toxicol Appl Pharmacol. 2001 Aug 17; 89(4):351-6. Koyama Y, Wang P, Liang S, Iwaisako K, Liu X, Xu J, Zhang M, Sun M, Cong M, Karin D, Taura K. Liver inflammation and fibrosis. Sols-Herruzo JA, Rippe RA, Schrum LW, de La Torre P, Garca I, Jeffrey JJ, Muoz-Yage T. NF-kappaB inhibits expression of the alpha1(I) collagen gene. Hepatology. Semaphorin 7A contributes to TGF--mediated liver fibrogenesis. 1998 Sep; 13 Suppl:S39-50. Circulation. 1991 Oct; 14(4 Pt 1):740-2. He will assume his new role effective September 14. 2001 Jan; 280(1):G139-48. Am J Pathol. 2008 Jul; 255(7):993-1000. Carethers will report directly to the chancellor and is part of the leadership team. Exp Biol Med (Maywood). Scholten D, Reichart D, Paik YH, Lindert J, Bhattacharya J, Glass CK. 1999 Apr 15; 162(8):4447-54. 2005 Nov; 29(11 Suppl):102S-109S. Luedde T, Assmus U, Wstefeld T, Meyer zu Vilsendorf A, Roskams T, Schmidt-Supprian M, Rajewsky K. Information assimilation and distribution challenges and goals for real and virtual journals. 2012 Nov; 143(5):1330-1340.e1. WebDavid Brenner is vice chancellor for health sciences at University of California San Diego. 2007 Jun 15; 462(2):266-72. Gastroenterology. Am J Physiol. 2008 Feb; 233(2):109-22. In vivo activation of mitogen-activated protein kinases in rat intestinal neoplasia. Aging Ment Health. J Gastroenterol Hepatol. 1998 Nov; 18(11):6353-64. Surgery. Mol Cell Biol. Scholarship Fund, Molecular Pathogenesis of Apoptosis in Liver Cells, ONCOGENIC K-RAS INDUCTION OF GASTRIN GENE TRANSCRIPTION, GENE TECHNOLOGY THERAPY AND ALCOHOL-INDUCED FIBROSIS, The Southern California Research Center for ALPD and Cirrhosis, Molecular and Cellular Pathogenesis in Alcoholism, MOLECULAR AND CELLULAR PATHOGENESIS IN ALCOHOLISM, FUNCTION OF NUCLEAR ONCOGENES IN CANCER CELLS, Molecular Mechanisms by which TNFalpha Modulates Fibrosis. Agreement between TOAST and CCS ischemic stroke classification: the NINDS SiGN study. Cell. 1998 08; 275(2):G269-78. 1990; 24:352-8. IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease. The mitochondrial permeability transition augments Fas-induced apoptosis in mouse hepatocytes. 2016; 7:17. 2021 07 20; 118(29). Gut Microbiome-Based Metagenomic Signature for Non-invasive Detection of Advanced Fibrosis in Human Nonalcoholic Fatty Liver Disease. Dig Dis Sci. Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha. Adachi M, Osawa Y, Uchinami H, Kitamura T, Accili D. Systemic mediators induce fibrogenic effects in normal liver after partial bile duct ligation. J Biol Chem. J Biol Chem. Iwaisako K, Haimerl M, Paik YH, Taura K, Kodama Y. 2001 Dec; 281(6):G1357-68. Alcohol Clin Exp Res. Mol Genet Genomic Med. 2007 Aug; 22(8):1256-64. 2012 Jun; 56(6):1283-92. Jun kinase modulates tumor necrosis factor-dependent apoptosis in liver cells. We were lucky to get them, said Dr. David Brenner, UCSDs vice chancellor of health sciences. 2007 Nov; 2(4):243-4. Sancho-Bru P, Bataller R, Fernandez-Varo G, Moreno M, Ramalho LN, Colmenero J, Mar M, Clria J, Jimnez W, Arroyo V. Epimorphin, a morphogenic protein, induces proteases in rodent hepatocytes through NF-kappaB. Tumor necrosis factor alpha-induced interleukin-8 production via NF-kappaB and phosphatidylinositol 3-kinase/Akt pathways inhibits cell apoptosis in human hepatocytes. Hepatology. 2012 Aug; 143(2):307-20. 2017 12 12; 8(1):2137. Front Biosci. Korean J Hepatol. Obesity and alcohol synergize to increase the risk of incident hepatocellular carcinoma in men. Exp Biol Med (Maywood). 2022 08 02; 34(8):1201-1213.e5. 2008 Sep; 5(9):496-7. Gbele E, Froh M, Arteel GE, Uesugi T, Hellerbrand C, Schlmerich J. Front Physiol. Gastroenterol Hepatol (N Y). 2010 Feb; 16(2):181-90. Nat Immunol. J Hepatol. Salicylate enhances necrosis and apoptosis mediated by the mitochondrial permeability transition. Alpha-1 antitrypsin Z protein (PiZ) increases hepatic fibrosis in a murine model of cholestasis. 2013 Jul; 145(1):16-31. 2008 Jul; 48(1):322-35. Am J Pathol. Yan AW, Fouts DE, Brandl J, St?rkel P, Torralba M, Schott E. Role and cellular source of nicotinamide adenine dinucleotide phosphate oxidase in hepatic fibrosis. Am J Physiol Gastrointest Liver Physiol. 2021 08; 74(2):667-685. Clin Gastroenterol Hepatol. Hepatic stellate cells and the reversal of fibrosis. Binding of upstream stimulatory factor to an E-box in the 3'-flanking region stimulates alpha1(I) collagen gene transcription. J Biol Chem. Hepatitis C virus core and nonstructural proteins induce fibrogenic effects in hepatic stellate cells. This site is running Profiles RNS version pre_new_search-4-g7119b7be on PROFILES-PWEB04. 2014 Dec; 60(6):1920-8. Gut. Am J Physiol. Medicina (Kaunas). A gut microbiome signature for cirrhosis due to nonalcoholic fatty liver disease. AIDS. Miura K, Yoshino R, Hirai Y, Goto T, Ohshima S, Mikami K, Yoneyama K, Watanabe D, Sato M, Senoo H, Kodama Y, Osawa Y. 1988 Jan-Feb; 8(1):176-82. Luedde T, Rodriguez ME, Tacke F, Xiong Y. J Biol Chem. 2015 Jan; 22(1):164-73. Mol Cell Biol. Cardiovascular health of nonagenarians in southern Italy: a cross-sectional, home-based pilot study of longevity. Effects of losartan on hepatic expression of nonphagocytic NADPH oxidase and fibrogenic genes in patients with chronic hepatitis C. Am J Physiol Gastrointest Liver Physiol. Liver regeneration is suppressed in small-for-size liver grafts after transplantation: involvement of c-Jun N-terminal kinase, cyclin D1, and defective energy supply. WebBrenners wife, Jill Silverman Brenner, M.D., is a primary care internist and rheumatologist. Gastroenterology. Deficiency of NOX1 or NOX4 Prevents Liver Inflammation and Fibrosis in Mice through Inhibition of Hepatic Stellate Cell Activation. Am J Physiol Gastrointest Liver Physiol. 2014 Jul 21; 5:4451. 2017 03; 15(3):463-464. 2007 Apr-Jun; 6(2):83-8. Rhoads JM, Argenzio RA, Chen W, Graves LM, Licato LL, Blikslager AT, Smith J, Gatzy J. Current and prospective therapies for hepatic fibrosis. Caussy C, Bhargava M, Villesen IF, Gudmann NS, Leeming DJ, Karsdal MA, Faulkner C, Bao D, Liu A, Lo MT, Bettencourt R, Bassirian S. The Role of Fibrosis and Liver-Associated Fibroblasts in the Pathogenesis of Hepatocellular Carcinoma. 2010 Sep; 139(3):836-45, 845.e1. Fibrogenesis Tissue Repair. Schrum LW, Bird MA, Salcher O, Burchardt ER, Grisham JW. 2014 Jun 10; 20(17):2854-72. Dig Dis. Hepatology. Lang A, Schrum LW, Schoonhoven R, Tuvia S, Sols-Herruzo JA. Increased expression of collagenase in the liver induces hepatocyte proliferation with cytoplasmic accumulation of beta-catenin in the rat. 2011 Jan; 53(1):96-105. Licato LL, Keku TO, Wurzelmann JI, Murray SC, Woosley JT, Sandler RS. 2012 Sep; 143(3):765-776.e3. Rippe RA, Umezawa A, Kimball JP, Breindl M. Growth inhibitory properties of endothelin-1 in activated human hepatic stellate cells: a cyclic adenosine monophosphate-mediated pathway. Cytokines induce NF-kappaB in activated but not in quiescent rat hepatic stellate cells. 2003 Feb; 37(2):267-76. Differential role of I kappa B kinase 1 and 2 in primary rat hepatocytes. Pizza V, Antonini P, Marino R, D'Arena G, Lucibello SG, Rizzo M. Functional Microbial Responses to Alcohol Abstinence in Patients With Alcohol Use Disorder. Miller AC, Rivas R, Tesoro L, Kovalenko G, Kovaric N, Pavlovic P. Increased Risk of Death, in the Hospital and Outside the Intensive Care Unit, for Patients With Cirrhosis After Cardiac Arrest. Mol Cell Biol. Ludin A, Itkin T, Gur-Cohen S, Mildner A, Shezen E, Golan K, Kollet O, Kalinkovich A, Porat Z, D'Uva G, Schajnovitz A, Voronov E. The single nucleotide polymorphism CRTh2 rs533116 is associated with allergic asthma and increased expression of CRTh2. Alcohol Clin Exp Res. Heterogeneity of HSCs in a Mouse Model of NASH. Lehnert M, Uehara T, Bradford BU, Lind H, Zhong Z. Mechanisms of Liver Injury. 2011 Jul; 31(6):762-72. 2010 Oct; 16(10):1152-6. An exon 10 deletion in the mouse ferrochelatase gene has a dominant-negative effect and causes mild protoporphyria. Data from arrays: an embarrassment of riches. 1999 Mar; 15(2):103-7. What's new in liver fibrosis? After being discharged, he attended Temple University, where he majored in mass communication and graduated with honors. Brenner was a writer, director or producer of 115 television documentaries and headed the documentary units of Westinghouse Broadcasting and Metromedia, winning nearly 30 awards including an Emmy, before moving to comedy. 2000 Dec; 279(6):G1333-42. Hepatology. 2017 Jun 16; 7:314-323. Vuori will 2017 10 16; 8(1):837. 2012; 7(4):e34218. 1995 Sep 29; 270(39):22689-92. J Biol Chem. J Clin Invest. J Hepatol. 2003 May; 73(1):44-52. 2004 Aug 15; 78(3):324-32. Ma HY, Yamamoto G, Xu J, Liu X, Karin D, Kim JY. 2020; 4(5):561-580. Park CC, Nguyen P, Hernandez C, Bettencourt R, Ramirez K, Fortney L, Hooker J, Sy E, Savides MT, Alquiraish MH, Valasek MA. Proc Natl Acad Sci U S A. Hepatology. The phenotypic fate and functional role for bone marrow-derived stem cells in liver fibrosis. Hepatology. J Theor Biol. WebPhilanthropist Hertzberg and his wife have provided major funding to UCSD for more than a decade and will continue to do so, he said. Gastroenterology. Blood. 2020 12 15; 95(24):e3163-e3179. Biochem Biophys Res Commun. Dr. David Brenner, UCSDs vice chancellor of health sciences, told the Union-Tribune, Were glad theres been a settlement. J Clin Invest. Rhoads JM, Argenzio RA, Chen W, Rippe RA, Westwick JK, Cox AD, Berschneider HM. PLoS One. DNA-mediated gene transfer into adult rat hepatocytes in primary culture. Hepatology. 1999 03; 276(3):G591-8. Hepatology. 2019 01; 49(2):183-193. 2006 Apr; 290(4):G583-9. Cell Metab. Mol Biol Med. Nishio T, Iimuro Y, Nitta T, Harada N, Yoshida M, Hirose T, Yamamoto N, Morimoto T. c-Jun-N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration. Nat Commun. Gene expression profiles during hepatic stellate cell activation in culture and in vivo. USC undermined our ability to do research. Semin Liver Dis. 1998 09; 275(3):G387-92. Cong M, Zhao W, Liu T, Wang P, Fan X, Zhai Q, Bao X, Zhang D, You H. Radiation exposure from depleted uranium: The radiation bystander effect. HBO Special recorded in Las 2019 03; 156(4):1156-1172.e6. Exp Neurol. 2018 07; 15(7):397-411. Mol Cell Biol. Proc Natl Acad Sci U S A. 2005 Dec; 42(6):1320-8. 2016 11; 64(5):1547-1558. 1989 Feb 16; 337(6208):661-3. J Hepatol. Decreasing fibrogenesis: an immunohistochemical study of paired liver biopsies following lamivudine therapy for chronic hepatitis B. J Hepatol. 1988 Sep-Oct; 8(5):1040-5. WebDavid BRENNER, Vice Chancellor for Health Sciences | Cited by 64,664 | of University of California, San Diego, California (UCSD) | Read 698 publications | Contact David BRENNER Lavalle PC, Labreuche J, Gongora-Rivera F, Jaramillo A. 2003 Mar; 37(3):653-64. Tumor necrosis factor alpha inhibits collagen gene transcription and collagen synthesis in cultured human fibroblasts. Gastroenterology. 2017 Apr 03; 127(4):1254-1270. Immunotherapy-based targeting of MSLN+ activated portal fibroblasts is a strategy for treatment of cholestatic liver fibrosis. 2002 Oct; 4(5):769-81. 2009 Jul; 119(7):1858-70. c-Jun N-terminal kinase-1 from hematopoietic cells mediates progression from hepatic steatosis to steatohepatitis and fibrosis in mice. FASEB J. Gastroenterology. Glutamine metabolism stimulates intestinal cell MAPKs by a cAMP-inhibitable, Raf-independent mechanism. 1999 Jan; 30(1):77-87. 2010 Oct; 52(4):1390-400. 1992 May; 4(5):43-58. During his tenure at UC San Diego, Health Sciences has seen major growth in facilities and research programs including the addition of the Sulpizio Family Cardiovascular Center, T. Denny Sanford Medical Brenner married Elizabeth Slater of New York, the mother of his sons Slade and Wyatt, in the closing minutes of his David Brenner: Back with a Vengeance! HBO Special recorded in Las Vegas, on February 19, 2000. Expression of insulin-like growth factor I by activated hepatic stellate cells reduces fibrogenesis and enhances regeneration after liver injury. 2006 Sep; 291(3):G456-63. Tacke F, Gbele E, Bataille F, Schwabe RF, Hellerbrand C, Klebl F, Straub RH, Luedde T, Manns MP, Trautwein C. The genetics of nonalcoholic fatty liver disease. 1994 Dec; 124(6):755-60. J Biol Chem. 2013 Mar; 37(6):630-9. Development of an animal model of chronic alcohol-induced pancreatitis in the rat. 2012 May 22; 109(21):E1369-76. 1999; 66:205-22. Brenner has also been listed as a lead researcher on UCSDs portion of the liver study. Tumor necrosis factor alpha in the pathogenesis of human and murine fulminant hepatic failure. 2003 Apr; 38(4):468-75. Clin Gastroenterol Hepatol. 2021 08 01; 321(2):H435-H445. 1995; (33):212-4. PLoS One. Proc Am Thorac Soc. Hepatitis C and alcohol: fundamental and translational research directions. Hepatic stellate cells primed with cytokines upregulate inflammation in response to peptidoglycan or lipoteichoic acid. Am J Physiol. Biochim Biophys Acta. 2006 Apr; 43(4):872-8. 2016; 7:47. 2004 Jun; 135(6):619-28. 2008 Feb; 47(2):677-85. Differential requirement for c-Jun NH2-terminal kinase in TNFalpha- and Fas-mediated apoptosis in hepatocytes. Regulatory elements in the 5'-flanking region and the first intron contribute to transcriptional control of the mouse alpha 1 type I collagen gene. 1999 Oct; 18(10):751-61. Koch KS, Fletcher RG, Grond MP, Inyang AI, Lu XP. Modlin IM, Adler G, Alexander K, Arnold R. Liver fibrosis. NADPH Oxidase 1 in Liver Macrophages Promotes Inflammation and Tumor Development in Mice. Kandil HM, Argenzio RA, Chen W, Berschneider HM, Stiles AD, Westwick JK, Rippe RA. Study of factors causing excess protoporphyrin accumulation in cultured skin fibroblasts from patients with protoporphyria. Utility of magnetic resonance imaging versus histology for quantifying changes in liver fat in nonalcoholic fatty liver disease trials. Yang L, Magness ST, Bataller R, Rippe RA. 1992 Jun; 50(6):1203-10. Hatano E, Bradham CA, Stark A, Iimuro Y, Lemasters JJ. 2007 Dec; 52(12):3404-15. J Hepatol. Inhibition of collagen alpha 1(I) expression by the 5' stem-loop as a molecular decoy. Activation of nuclear factor-kappaB during orthotopic liver transplantation in rats is protective and does not require Kupffer cells. J Hepatol. Hepatitis C virus-induced oxidative stress suppresses hepcidin expression through increased histone deacetylase activity. A method for in vitro DNase I footprinting analysis on supercoiled templates. Nat Rev Gastroenterol Hepatol. 2015 Feb; 4(1):34-47. Meurer SK, Alsamman M, Sahin H, Wasmuth HE. J Hepatol. Reduced nicotinamide adenine dinucleotide phosphate oxidase mediates fibrotic and inflammatory effects of leptin on hepatic stellate cells. Cytokine polymorphisms associated with carotid intima-media thickness in stroke patients. Bataller R, Schwabe RF, Choi YH, Yang L, Paik YH, Lindquist J, Qian T, Schoonhoven R, Hagedorn CH, Lemasters JJ. Cell Metab. Cancer Res. 15th International Symposium on Cells of the Hepatic Sinusoid, 2010. 2006 Jul; 86(7):676-86. 2022 Oct 28; 11(11). Next-generation academic medicine. 1992 Sep 04; 70(5):777-89. 2012 Sep; 56(3):922-32. CX3CL1-CX3CR1 interaction prevents carbon tetrachloride-induced liver inflammation and fibrosis in mice. In 2012, Jacobs and his wife, Joan, jumpstarted the People who share similar concepts with this person. Hepatology. 2004 Jun; 40(6):942-51. Sanz S, Pucilowska JB, Liu S, Rodrguez-Ortigosa CM, Lund PK. Baglieri J, Zhang C, Liang S, Liu X, Nishio T. Nonalcoholic Steatohepatitis and HCC in a Hyperphagic Mouse Accelerated by Western Diet. Celecoxib induces hepatic stellate cell apoptosis through inhibition of Akt activation and suppresses hepatic fibrosis in rats. This graph shows the total number of publications by year. 2006 Nov; 26(9):1138-47. Clin Liver Dis. TAK1/JNK and p38 have opposite effects on rat hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol. 2000 Nov; 119(5):1399-401. Magness ST, Tugores A, Christensen SR, Wagner-Mcpherson C, Evans GA, Naylor EW. 2000 Jan; 118(1):90-100. 2016 Feb 10; 19(2):227-39. Differential requirement for NF-kappaB-inducing kinase in the induction of NF-kappaB by IL-1beta, TNF-alpha, and Fas. 1990 Dec; 9(10):777-81. Human hepatic stellate cell isolation and characterization. Studies with human cultured skin fibroblasts. 2012 Jul; 36(1):22-9. Mutation of the 5'-untranslated region stem-loop structure inhibits a1(I) collagen expression in vivo. 2015 Apr 06; 212(4):469-80. Hepatology. Liver Int. Int J Mol Med. 2004 Nov; 40(5):1151-9. Magnetic resonance elastography identifies fibrosis in adults with alpha-1 antitrypsin deficiency liver disease: a prospective study. 2015 Jul; 22(7):512-8. J Clin Invest. J Clin Invest. J Clin Exp Hepatol. Biochem Biophys Res Commun. Bradham CA, Qian T, Streetz K, Trautwein C. NF-kappaB inactivation converts a hepatocyte cell line TNF-alpha response from proliferation to apoptosis. Biotechniques. 2000 Mar-Apr; 21(2):135-41. 1998; 8(3-4):283-5. Migration of fibrocytes in fibrogenic liver injury. Placebo-controlled trial of high-dose atorvastatin in patients with severe cerebral small vessel disease. Nat Rev Gastroenterol Hepatol. Molecular mechanisms of alcohol-induced hepatic fibrosis. 2015 Dec; 149(7):1784-93. 2003 Apr 15; 170(8):4053-60. 1991 12; 54(6 Suppl):1141S-1143S. Hum Mol Genet. Front Physiol. Identification of Novel Fibrosis Modifiers by InVivo siRNA Silencing. Bataller R, Paik YH, Lindquist JN, Lemasters JJ. Nat Rev Gastroenterol Hepatol. Protection from liver fibrosis by a peroxisome proliferator-activated receptor d agonist. Moderate alcohol drinking: effects on the heart and liver. Ital J Gastroenterol Hepatol. 2019 01; 17(2):218-230. 2003 Sep; 285(3):G642-51. Kweon YO, Goodman ZD, Dienstag JL, Schiff ER, Brown NA, Burchardt E, Schoonhoven R. Akt protects mouse hepatocytes from TNF-alpha- and Fas-mediated apoptosis through NK-kappa B activation. Alcohol Clin Exp Res. Role of Gut Microbiota in Liver Disease. 1998 Sep; 13 Suppl:S93-5. WebName Division; Curtius, Kathleen Mary: Biomedical Informatics: El-Kareh, Robert E, MD: Biomedical Informatics: Harismendy, Olivier, MD: Biomedical Informatics Taura K, Miura K, Iwaisako K, Osterreicher CH, Kodama Y, Penz-Osterreicher M. Reduction of advanced liver fibrosis by short-term targeted delivery of an angiotensin receptor blocker to hepatic stellate cells in rats. Delivery of matrix metalloproteinase-1 attenuates established liver fibrosis in the rat. Alcohol causes both tolerance and sensitization of rat Kupffer cells via mechanisms dependent on endotoxin. 2004 Feb; 126(2):529-40. The role of NF-kappaB in hepatocarcinogenesis: promoter or suppressor? 1990 Nov; 26(11):1011-23. Uehara T, Xi Peng X, Bennett B, Satoh Y, Friedman G, Currin R. In vivo pattern of lipopolysaccharide and anti-CD3-induced NF-kappa B activation using a novel gene-targeted enhanced GFP reporter gene mouse. A role for lipid peroxidation? Itsumi M, Inoue S, Elia AJ, Murakami K, Sasaki M, Lind EF. Neurogastroenterol Motil. 2003 Mar; 37(3):493-503. Curr Pathobiol Rep. 2016 Mar; 4(1):27-35. J Gastroenterol Hepatol. Achievement of optimal medical therapy goals for U.S. adults with coronary artery disease: results from the REGARDS Study (REasons for Geographic And Racial Differences in Stroke). Fibrogenesis and type I collagen gene regulation. 2006 Oct; 21 Suppl 3:S84-7. Lab Invest. 1993 Feb; 17(2):287-92. Nelson K, Foufoula-Georgiou E, Gelfand M. The role of Mesothelin signaling in Portal Fibroblasts in the pathogenesis of cholestatic liver fibrosis. , Xu J, Glass CK 1-phosphate in regulating hepatocyte apoptosis is associated carotid. Fas-Induced apoptosis in normal rat liver repeat profiling of immortalized hepatic stellate cell biology with arrayed combinatorial.! Fibrotic liver in mice human and murine fulminant hepatic failure ; 170 ( 8 ):4447-54 induces proliferation! 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